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Probing the electrostatics and pharmacologic modulation of sequence-specific binding by the DNA-binding domain of the ETS-family transcription factor PU.1: a binding affinity and kinetics investigation

Members of the ETS family of transcription factors regulate a functionally diverse array of genes. All ETS proteins share a structurally-conserved but sequence-divergent DNA-binding domain, known as the ETS domain. Although the structure and thermodynamics of the ETS-DNA complexes are well known, li...

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Detalhes bibliográficos
Main Authors: Munde, Manoj, Poon, Gregory M. K., Wilson, W. David
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762459/
https://ncbi.nlm.nih.gov/pubmed/23416556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2013.02.010
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