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Sequence Discrimination by DNA-binding Domain of ETS Family Transcription Factor PU.1 Is Linked to Specific Hydration of Protein-DNA Interface
PU.1 is an essential transcription factor in normal hematopoietic lineage development. It recognizes a large number of promoter sites differing only in bases flanking a core consensus of 5′-GGAA-3′. DNA binding is mediated by its ETS domain, whose sequence selectivity directly corresponds to the tra...
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| Format: | Artigo |
| Jezik: | Inglês |
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American Society for Biochemistry and Molecular Biology
2012
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3365747/ https://ncbi.nlm.nih.gov/pubmed/22474303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.342345 |
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