Mechanistic Heterogeneity in Site Recognition by the Structurally Homologous DNA-binding Domains of the ETS Family Transcription Factors Ets-1 and PU.1

ETS family transcription factors regulate diverse genes through binding at cognate DNA sites that overlap substantially in sequence. The DNA-binding domains of ETS proteins (ETS domains) are highly conserved structurally yet share limited amino acid homology. To define the mechanistic implications o...

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Main Authors: Wang, Shuo, Linde, Miles H., Munde, Manoj, Carvalho, Victor D., Wilson, W. David, Poon, Gregory M. K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118120/
https://ncbi.nlm.nih.gov/pubmed/24952944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.575340
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