Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes

The Hace1-HECT E3 ligase is a tumor suppressor that ubiquitylates the activated GTP-bound form of the Rho family GTPase Rac1, leading to Rac1 proteasomal degradation. Here we show that, in vertebrates, Hace1 targets Rac1 for degradation when Rac1 is localized to the nicotinamide adenine dinucleotide...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Daugaard, Mads, Nitsch, Roberto, Razaghi, Babak, McDonald, Lindsay, Jarrar, Ameer, Torrino, Stéphanie, Castillo-Lluva, Sonia, Rotblat, Barak, Li, Liheng, Malliri, Angeliki, Lemichez, Emmanuel, Mettouchi, Amel, Berman, Jason N., Penninger, Josef M., Sorensen, Poul H.
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759041/
https://ncbi.nlm.nih.gov/pubmed/23864022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3180
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars