Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction

Cellular transformation is associated with altered glutamine (Gln) metabolism. Tumor cells utilize Gln in the tricarboxylic acid (TCA) cycle to maintain sufficient pools of biosynthetic precursors to support rapid growth and proliferation. However, Gln metabolism also generates NADPH, and Gln-derive...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Cetinbas, Naniye, Daugaard, Mads, Mullen, Andrew, Hajee, Shamil, Rotblat, Barak, Lopez, Alejandra, Li, Amy, DeBerardinis, Ralph J, Sorensen, Poul H
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387113/
https://ncbi.nlm.nih.gov/pubmed/25284589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.316
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