Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction

Cellular transformation is associated with altered glutamine (Gln) metabolism. Tumor cells utilize Gln in the tricarboxylic acid (TCA) cycle to maintain sufficient pools of biosynthetic precursors to support rapid growth and proliferation. However, Gln metabolism also generates NADPH, and Gln-derive...

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Publicat a:Oncogene
Autors principals: Cetinbas, Naniye, Daugaard, Mads, Mullen, Andrew, Hajee, Shamil, Rotblat, Barak, Lopez, Alejandra, Li, Amy, DeBerardinis, Ralph J, Sorensen, Poul H
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387113/
https://ncbi.nlm.nih.gov/pubmed/25284589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.316
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