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Loss of the tumor suppressor Hace1 leads to ROS-dependent glutamine addiction
Cellular transformation is associated with altered glutamine (Gln) metabolism. Tumor cells utilize Gln in the tricarboxylic acid (TCA) cycle to maintain sufficient pools of biosynthetic precursors to support rapid growth and proliferation. However, Gln metabolism also generates NADPH, and Gln-derive...
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| 出版年: | Oncogene |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4387113/ https://ncbi.nlm.nih.gov/pubmed/25284589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.316 |
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