Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes

The Hace1-HECT E3 ligase is a tumor suppressor that ubiquitylates the activated GTP-bound form of the Rho family GTPase Rac1, leading to Rac1 proteasomal degradation. Here we show that, in vertebrates, Hace1 targets Rac1 for degradation when Rac1 is localized to the nicotinamide adenine dinucleotide...

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Main Authors: Daugaard, Mads, Nitsch, Roberto, Razaghi, Babak, McDonald, Lindsay, Jarrar, Ameer, Torrino, Stéphanie, Castillo-Lluva, Sonia, Rotblat, Barak, Li, Liheng, Malliri, Angeliki, Lemichez, Emmanuel, Mettouchi, Amel, Berman, Jason N., Penninger, Josef M., Sorensen, Poul H.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3759041/
https://ncbi.nlm.nih.gov/pubmed/23864022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3180
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