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Competition Between Homodimerization and Cholesterol Binding to the C99 Domain of the Amyloid Precursor Protein
The 99 residue transmembrane C-terminal domain (C99, also known as β-CTF) of the amyloid precursor protein (APP) is the product of β-secretase cleavage of full length APP and the substrate for γ-secretase cleavage. The latter cleavage releases the amyloid-β polypeptides that are closely associated w...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3758481/ https://ncbi.nlm.nih.gov/pubmed/23865807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400735x |
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