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Competition Between Homodimerization and Cholesterol Binding to the C99 Domain of the Amyloid Precursor Protein

The 99 residue transmembrane C-terminal domain (C99, also known as β-CTF) of the amyloid precursor protein (APP) is the product of β-secretase cleavage of full length APP and the substrate for γ-secretase cleavage. The latter cleavage releases the amyloid-β polypeptides that are closely associated w...

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Autors principals: Song, Yuanli, Hustedt, Eric J., Brandon, Suzanne, Sanders, Charles R.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3758481/
https://ncbi.nlm.nih.gov/pubmed/23865807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400735x
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