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The Amyloid Precursor Protein has a Flexible Transmembrane Domain and Binds Cholesterol

C99 is the transmembrane carboxyl-terminal domain of the amyloid precursor protein that is cleaved by γ-secretase to release the amyloid-β polypeptides, which are associated with Alzheimer’s disease. Nuclear magnetic resonance and electron paramagnetic resonance spectroscopy show that the extracellu...

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Dettagli Bibliografici
Autori principali: Barrett, Paul J., Song, Yuanli, Van Horn, Wade D., Hustedt, Eric J., Schafer, Johanna M., Hadziselimovic, Arina, Beel, Andrew J., Sanders, Charles R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528355/
https://ncbi.nlm.nih.gov/pubmed/22654059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1219988
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