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The Amyloid Precursor Protein has a Flexible Transmembrane Domain and Binds Cholesterol
C99 is the transmembrane carboxyl-terminal domain of the amyloid precursor protein that is cleaved by γ-secretase to release the amyloid-β polypeptides, which are associated with Alzheimer’s disease. Nuclear magnetic resonance and electron paramagnetic resonance spectroscopy show that the extracellu...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3528355/ https://ncbi.nlm.nih.gov/pubmed/22654059 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1219988 |
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