The Amyloid Precursor Protein has a Flexible Transmembrane Domain and Binds Cholesterol

C99 is the transmembrane carboxyl-terminal domain of the amyloid precursor protein that is cleaved by γ-secretase to release the amyloid-β polypeptides, which are associated with Alzheimer’s disease. Nuclear magnetic resonance and electron paramagnetic resonance spectroscopy show that the extracellu...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Barrett, Paul J., Song, Yuanli, Van Horn, Wade D., Hustedt, Eric J., Schafer, Johanna M., Hadziselimovic, Arina, Beel, Andrew J., Sanders, Charles R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528355/
https://ncbi.nlm.nih.gov/pubmed/22654059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1219988
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge