The C99 domain of the amyloid precursor protein resides in the disordered membrane phase

Processing of the amyloid precursor protein (APP) via the amyloidogenic pathway is associated with the etiology of Alzheimer’s disease. The cleavage of APP by β-secretase to generate the transmembrane 99-residue C-terminal fragment (C99) and subsequent processing of C99 by γ-secretase to yield amylo...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Capone, Ricardo, Tiwari, Ajit, Hadziselimovic, Arina, Peskova, Yelena, Hutchison, James M., Sanders, Charles R., Kenworthy, Anne K.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2021
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113881/
https://ncbi.nlm.nih.gov/pubmed/33839158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100652
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