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The C99 domain of the amyloid precursor protein resides in the disordered membrane phase
Processing of the amyloid precursor protein (APP) via the amyloidogenic pathway is associated with the etiology of Alzheimer’s disease. The cleavage of APP by β-secretase to generate the transmembrane 99-residue C-terminal fragment (C99) and subsequent processing of C99 by γ-secretase to yield amylo...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8113881/ https://ncbi.nlm.nih.gov/pubmed/33839158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100652 |
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