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Structural Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein (APP): Does APP Function as a Cholesterol Sensor?(,)

The amyloid precursor protein (APP) is subject to alternative pathways of proteolytic processing, leading either to production of the amyloid-β (Aβ) peptides or to non-amyloidogenic fragments. Here, we report the first structural study of C99, the 99-residue transmembrane C-terminal domain of APP li...

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Autori principali: Beel, Andrew J., Mobley, Charles K., Kim, Hak Jun, Tian, Fang, Hadziselimovic, Arina, Jap, Bing, Prestegard, James H., Sanders, Charles R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572687/
https://ncbi.nlm.nih.gov/pubmed/18702528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800993c
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