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Direct Binding of Cholesterol to the Amyloid Precursor Protein: An Important Interaction in Lipid-Alzheimer’s Disease Relationships?

It is generally believed that cholesterol homoeostasis in the brain is both linked to and impacted by Alzheimer’s disease (AD). For example, elevated levels of cholesterol in neuronal plasma and endosome membranes appears to be a pro-amyloidogenic factor. The recent observation that the C-terminal t...

詳細記述

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書誌詳細
主要な著者: Beel, Andrew J., Sakakura, Masayoshi, Barrett, Paul J., Sanders, Charles R.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886191/
https://ncbi.nlm.nih.gov/pubmed/20304095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2010.03.008
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