Direct Binding of Cholesterol to the Amyloid Precursor Protein: An Important Interaction in Lipid-Alzheimer’s Disease Relationships?

It is generally believed that cholesterol homoeostasis in the brain is both linked to and impacted by Alzheimer’s disease (AD). For example, elevated levels of cholesterol in neuronal plasma and endosome membranes appears to be a pro-amyloidogenic factor. The recent observation that the C-terminal t...

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Bibliographic Details
Main Authors: Beel, Andrew J., Sakakura, Masayoshi, Barrett, Paul J., Sanders, Charles R.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886191/
https://ncbi.nlm.nih.gov/pubmed/20304095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2010.03.008
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