Disrupting malaria parasite AMA1 – RON2 interaction with a small molecule prevents erythrocyte invasion

Plasmodium falciparumresistance to artemisinin derivatives, the first-line anti-malarial drug, drives the search for new classes of chemotherapeutic agents. Current discovery is primarily directed against the intracellular forms of the parasite. However, late schizont-infected red blood cells (RBCs)...

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Detalhes bibliográficos
Main Authors: Srinivasan, Prakash, Yasgar, Adam, Luci, Diane K., Beatty, Wandy L., Hu, Xin, Andersen, John, Narum, David L., Moch, J. Kathleen, Sun, Hongmao, Haynes, J. David, Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Miller, Louis H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3755449/
https://ncbi.nlm.nih.gov/pubmed/23907321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3261
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