Steroids as γ-secretase modulators

Aggregation and accumulation of Aβ(42) play an initiating role in Alzheimer's disease (AD); thus, selective lowering of Aβ(42) by γ-secretase modulators (GSMs) remains a promising approach to AD therapy. Based on evidence suggesting that steroids may influence Aβ production, we screened 170 ste...

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Bibliographic Details
Main Authors: Jung, Joo In, Ladd, Thomas B., Kukar, Thomas, Price, Ashleigh R., Moore, Brenda D., Koo, Edward H., Golde, Todd E., Felsenstein, Kevin M.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2013
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3752532/
https://ncbi.nlm.nih.gov/pubmed/23716494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-225649
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