טוען...
Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing
Persistence of human fetal hemoglobin (HbF, α(2)γ(2)) in adults lessens the severity of sickle cell disease (SCD) and the β-thalassemias. Here, we show that the repressor BCL11A is required in vivo for silencing of γ-globin expression in adult animals, yet dispensable for red cell production. BCL11A...
שמור ב:
| Main Authors: | , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2011
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3746545/ https://ncbi.nlm.nih.gov/pubmed/21998251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1211053 |
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