Correction of Sickle Cell Disease in Adult Mice by Interference with Fetal Hemoglobin Silencing

Persistence of human fetal hemoglobin (HbF, α(2)γ(2)) in adults lessens the severity of sickle cell disease (SCD) and the β-thalassemias. Here, we show that the repressor BCL11A is required in vivo for silencing of γ-globin expression in adult animals, yet dispensable for red cell production. BCL11A...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Xu, Jian, Peng, Cong, Sankaran, Vijay G., Shao, Zhen, Esrick, Erica B., Chong, Bryan G., Ippolito, Gregory C., Fujiwara, Yuko, Ebert, Benjamin L., Tucker, Philip W., Orkin, Stuart H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2011
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3746545/
https://ncbi.nlm.nih.gov/pubmed/21998251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1211053
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