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Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.

Hydroxyurea, a widely used cytotoxic/cytostatic agent that does not influence methylation of DNA bases, increases fetal hemoglobin production in anemic monkeys. To determine its effect in sickle cell anemia, we treated two patients with a total of four, 5-d courses (50 mg/kg per d, divided into thre...

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Dettagli Bibliografici
Autori principali: Platt, O S, Orkin, S H, Dover, G, Beardsley, G P, Miller, B, Nathan, D G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1984
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC370519/
https://ncbi.nlm.nih.gov/pubmed/6205021
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