Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia.

Hydroxyurea, a widely used cytotoxic/cytostatic agent that does not influence methylation of DNA bases, increases fetal hemoglobin production in anemic monkeys. To determine its effect in sickle cell anemia, we treated two patients with a total of four, 5-d courses (50 mg/kg per d, divided into thre...

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Publié dans:	J Clin Invest
Auteurs principaux:	Platt, O S, Orkin, S H, Dover, G, Beardsley, G P, Miller, B, Nathan, D G
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1984
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370519/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6205021/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111464
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