Synthesis and QSAR of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-Portion of Biphenyl-3-yl Alkylcarbamates

Alkylcarbamic acid biphenyl-3-yl esters are a class of fatty acid amide hydrolase (FAAH) inhibitors that comprises cyclohexylcarbamic acid 3′-carbamoylbiphenyl-3-yl ester (URB597), a compound with analgesic, anxiolytic-like and antidepressant-like properties in rat and mouse models. Here, we extende...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mor, Marco, Lodola, Alessio, Rivara, Silvia, Vacondio, Federica, Duranti, Andrea, Tontini, Andrea, Sanchini, Silvano, Piersanti, Giovanni, Clapper, Jason R., King, Alvin R., Tarzia, Giorgio, Piomelli, Daniele
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2008
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744893/
https://ncbi.nlm.nih.gov/pubmed/18507372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm701631z
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