Design and Synthesis of Potent “Sulfur-free” Transition State Analogue Inhibitors of 5′-Methylthioadenosine Nucleosidase and 5′-Methylthioadenosine Phosphorylase

5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN) is a dual substrate bacterial enzyme involved in S-adenosylmethionine (SAM)-related quorum sensing pathways that regulates virulence in many bacterial species. MTANs from many bacteria are directly involved in the quorum sensing mecha...

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Bibliographic Details
Main Authors: Longshaw, Alistair I., Adanitsch, Florian, Gutierrez, Jemy A., Evans, Gary B., Tyler, Peter C., Schramm, Vern L.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3742014/
https://ncbi.nlm.nih.gov/pubmed/20718423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100898v
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