Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau

BACKGROUND: The microtubule associated protein tau accumulates in neurodegenerative diseases known as tauopathies, the most common being Alzheimer’s disease (AD). One way to treat these disorders may be to reduce abnormal tau levels through chaperone manipulation, thus subverting synaptic plasticity...

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Main Authors: Abisambra, Jose, Jinwal, Umesh K., Miyata, Yoshinari, Rogers, Justin, Blair, Laura, Li, Xiaokai, Seguin, Sandlin P., Wang, Li, Jin, Ying, Bacon, Justin, Brady, Sarah, Cockman, Matthew, Guidi, Chantal, Zhang, Juan, Koren, John, Young, Zapporah T., Atkins, Christopher A., Zhang, Bo, Lawson, Lisa Y., Weeber, Edwin J., Brodsky, Jeffrey L., Gestwicki, Jason E., Dickey, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740016/
https://ncbi.nlm.nih.gov/pubmed/23607970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2013.02.027
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