Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil

5-Fluorouracil (5-FU) is the first rationally designed antimetabolite, which achieves its therapeutic efficacy through inhibition of the enzyme thymidylate synthase (TS), which is essential for the synthesis and repair of DNA. However, prolonged exposure to 5-FU induces TS overexpression, which lead...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Vinod, B S, Antony, J, Nair, H H, Puliyappadamba, V T, Saikia, M, Shyam Narayanan, S, Bevin, A, John Anto, R
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2013
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734809/
https://ncbi.nlm.nih.gov/pubmed/23429291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.26
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