Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil

5-Fluorouracil (5-FU) is the first rationally designed antimetabolite, which achieves its therapeutic efficacy through inhibition of the enzyme thymidylate synthase (TS), which is essential for the synthesis and repair of DNA. However, prolonged exposure to 5-FU induces TS overexpression, which lead...

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Detalhes bibliográficos
Main Authors: Vinod, B S, Antony, J, Nair, H H, Puliyappadamba, V T, Saikia, M, Shyam Narayanan, S, Bevin, A, John Anto, R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734809/
https://ncbi.nlm.nih.gov/pubmed/23429291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.26
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