Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil

5-Fluorouracil (5-FU) is the first rationally designed antimetabolite, which achieves its therapeutic efficacy through inhibition of the enzyme thymidylate synthase (TS), which is essential for the synthesis and repair of DNA. However, prolonged exposure to 5-FU induces TS overexpression, which lead...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Vinod, B S, Antony, J, Nair, H H, Puliyappadamba, V T, Saikia, M, Shyam Narayanan, S, Bevin, A, John Anto, R
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2013
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3734809/
https://ncbi.nlm.nih.gov/pubmed/23429291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.26
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