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Monitoring the Antioxidant Mediated Chemosensitization and ARE-Signaling in Triple Negative Breast Cancer Therapy.
Chemotherapy often fails due to cellular detoxifying mechanisms, including phase-II enzymes. Activation of Nrf2-Keap1 pathway induces phase-II enzymes expression through ARE-signaling and prevents cancer development. Nrf2-overexpression in cancer cells results in chemo- and/or radioresistance. This...
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Autors principals: | , , |
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Format: | Artigo |
Idioma: | Inglês |
Publicat: |
Public Library of Science (PLoS)
2015-01-01
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Col·lecció: | PLoS ONE |
Accés en línia: | http://europepmc.org/articles/PMC4633093?pdf=render |
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