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Monitoring the Antioxidant Mediated Chemosensitization and ARE-Signaling in Triple Negative Breast Cancer Therapy

Chemotherapy often fails due to cellular detoxifying mechanisms, including phase-II enzymes. Activation of Nrf2-Keap1 pathway induces phase-II enzymes expression through ARE-signaling and prevents cancer development. Nrf2-overexpression in cancer cells results in chemo- and/or radioresistance. This...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Foygel, Kira, Sekar, Thillai V., Paulmurugan, Ramasamy
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633093/
https://ncbi.nlm.nih.gov/pubmed/26536456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141913
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