Ultrasound-guided delivery of thymidine kinase–nitroreductase dual therapeutic genes by PEGylated-PLGA/PIE nanoparticles for enhanced triple negative breast cancer therapy

AIM: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. Since no targeted therapy is available, gene-directed enzyme prodrug therapy (GDEPT) could be an attractive strategy for treating TNBC. MATERIALS & METHODS: Polyethylene glycol (PEG)ylated-poly(lactic-co-glycolic a...

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Bibliographic Details
Published in:Nanomedicine (Lond)
Main Authors: Devulapally, Rammohan, Lee, Taehwa, Barghava-Shah, Aarohi, Sekar, Thillai V, Foygel, Kira, Bachawal, Sunitha V, Willmann, Jürgen K, Paulmurugan, Ramasamy
Format: Artigo
Language:Inglês
Published: Future Medicine Ltd 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219432/
https://ncbi.nlm.nih.gov/pubmed/29790803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm-2017-0328
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