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Degron Protease Blockade Sensor to Image Epigenetic Histone Protein Methylation in Cells and Living Animals

[Image: see text] Lysine methylation of histone H3 and H4 has been identified as a promising therapeutic target in treating various cellular diseases. The availability of an in vivo assay that enables rapid screening and preclinical evaluation of drugs that potentially target this cellular process w...

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Библиографические подробности
Опубликовано в: :ACS Chem Biol
Главные авторы: Sekar, Thillai V., Foygel, Kira, Devulapally, Rammohan, Paulmurugan, Ramasamy
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301175/
https://ncbi.nlm.nih.gov/pubmed/25489787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb5008037
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