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Degron Protease Blockade Sensor to Image Epigenetic Histone Protein Methylation in Cells and Living Animals

[Image: see text] Lysine methylation of histone H3 and H4 has been identified as a promising therapeutic target in treating various cellular diseases. The availability of an in vivo assay that enables rapid screening and preclinical evaluation of drugs that potentially target this cellular process w...

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Veröffentlicht in:ACS Chem Biol
Hauptverfasser: Sekar, Thillai V., Foygel, Kira, Devulapally, Rammohan, Paulmurugan, Ramasamy
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301175/
https://ncbi.nlm.nih.gov/pubmed/25489787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb5008037
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