Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation

In Alzheimer's disease (AD), the mechanisms of neuronal loss remain largely unknown. Although tau pathology is closely correlated with neuronal loss, how its accumulation may lead to activation of neurotoxic pathways is unclear. Here we show that tau increased the levels of ubiquitinated protei...

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Detalhes bibliográficos
Main Authors: Abisambra, Jose F., Jinwal, Umesh K., Blair, Laura J., O'Leary, John C., Li, Qingyou, Brady, Sarah, Wang, Li, Guidi, Chantal E., Zhang, Bo, Nordhues, Bryce A., Cockman, Matthew, Suntharalingham, Amirthaa, Li, Pengfei, Jin, Ying, Atkins, Christopher A., Dickey, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733249/
https://ncbi.nlm.nih.gov/pubmed/23719816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5397-12.2013
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