Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation

In Alzheimer's disease (AD), the mechanisms of neuronal loss remain largely unknown. Although tau pathology is closely correlated with neuronal loss, how its accumulation may lead to activation of neurotoxic pathways is unclear. Here we show that tau increased the levels of ubiquitinated protei...

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Main Authors: Abisambra, Jose F., Jinwal, Umesh K., Blair, Laura J., O'Leary, John C., Li, Qingyou, Brady, Sarah, Wang, Li, Guidi, Chantal E., Zhang, Bo, Nordhues, Bryce A., Cockman, Matthew, Suntharalingham, Amirthaa, Li, Pengfei, Jin, Ying, Atkins, Christopher A., Dickey, Chad A.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3733249/
https://ncbi.nlm.nih.gov/pubmed/23719816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5397-12.2013
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