Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway

NOD2 is an intracellular pattern recognition receptor that assembles with receptor-interacting protein (RIP)-2 kinase in response to the presence of bacterial muramyl dipeptide (MDP) in the host cell cytoplasm, thereby inducing signals leading to the production of pro-inflammatory cytokines. The dys...

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Autores principales: Rickard, David J., Sehon, Clark A., Kasparcova, Viera, Kallal, Lorena A., Zeng, Xin, Montoute, Monica N., Chordia, Tushar, Poore, Derek D., Li, Hu, Wu, Zining, Eidam, Patrick M., Haile, Pamela A., Yu, Jong, Emery, John G., Marquis, Robert W., Gough, Peter J., Bertin, John
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731320/
https://ncbi.nlm.nih.gov/pubmed/23936340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069619
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