Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway

NOD2 is an intracellular pattern recognition receptor that assembles with receptor-interacting protein (RIP)-2 kinase in response to the presence of bacterial muramyl dipeptide (MDP) in the host cell cytoplasm, thereby inducing signals leading to the production of pro-inflammatory cytokines. The dys...

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Detalhes bibliográficos
Main Authors: Rickard, David J., Sehon, Clark A., Kasparcova, Viera, Kallal, Lorena A., Zeng, Xin, Montoute, Monica N., Chordia, Tushar, Poore, Derek D., Li, Hu, Wu, Zining, Eidam, Patrick M., Haile, Pamela A., Yu, Jong, Emery, John G., Marquis, Robert W., Gough, Peter J., Bertin, John
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731320/
https://ncbi.nlm.nih.gov/pubmed/23936340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069619
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