Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway

NOD2 is an intracellular pattern recognition receptor that assembles with receptor-interacting protein (RIP)-2 kinase in response to the presence of bacterial muramyl dipeptide (MDP) in the host cell cytoplasm, thereby inducing signals leading to the production of pro-inflammatory cytokines. The dys...

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Main Authors: Rickard, David J., Sehon, Clark A., Kasparcova, Viera, Kallal, Lorena A., Zeng, Xin, Montoute, Monica N., Chordia, Tushar, Poore, Derek D., Li, Hu, Wu, Zining, Eidam, Patrick M., Haile, Pamela A., Yu, Jong, Emery, John G., Marquis, Robert W., Gough, Peter J., Bertin, John
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3731320/
https://ncbi.nlm.nih.gov/pubmed/23936340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069619
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