Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway

NOD1 is an intracellular pattern recognition receptor that recognizes diaminopimelic acid (DAP), a peptidoglycan component in gram negative bacteria. Upon ligand binding, NOD1 assembles with receptor-interacting protein (RIP)-2 kinase and initiates a signaling cascade leading to the production of pr...

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Hlavní autoři: Rickard, David J., Sehon, Clark A., Kasparcova, Viera, Kallal, Lorena A., Haile, Pamela A., Zeng, Xin, Montoute, Monica N., Poore, Derek D., Li, Hu, Wu, Zining, Eidam, Patrick M., Emery, John G., Marquis, Robert W., Gough, Peter J., Bertin, John
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013053/
https://ncbi.nlm.nih.gov/pubmed/24806487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096737
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