Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway

NOD1 is an intracellular pattern recognition receptor that recognizes diaminopimelic acid (DAP), a peptidoglycan component in gram negative bacteria. Upon ligand binding, NOD1 assembles with receptor-interacting protein (RIP)-2 kinase and initiates a signaling cascade leading to the production of pr...

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Main Authors: Rickard, David J., Sehon, Clark A., Kasparcova, Viera, Kallal, Lorena A., Haile, Pamela A., Zeng, Xin, Montoute, Monica N., Poore, Derek D., Li, Hu, Wu, Zining, Eidam, Patrick M., Emery, John G., Marquis, Robert W., Gough, Peter J., Bertin, John
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013053/
https://ncbi.nlm.nih.gov/pubmed/24806487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096737
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