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A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1
The mTOR Complex 1 (mTORC1) pathway promotes cell growth in response to many cues, including amino acids, which act through the Rag GTPases to promote mTORC1 translocation to the lysosomal surface, its site of activation. Although progress has been made in identifying positive regulators of the Rags...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3728654/ https://ncbi.nlm.nih.gov/pubmed/23723238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1232044 |
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