A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

The mTOR Complex 1 (mTORC1) pathway promotes cell growth in response to many cues, including amino acids, which act through the Rag GTPases to promote mTORC1 translocation to the lysosomal surface, its site of activation. Although progress has been made in identifying positive regulators of the Rags...

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Bibliografiske detaljer
Main Authors: Bar-Peled, Liron, Chantranupong, Lynne, Cherniack, Andrew D., Chen, Walter W., Ottina, Kathleen A., Grabiner, Brian C., Spear, Eric D., Carter, Scott L., Meyerson, Matthew, Sabatini, David M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728654/
https://ncbi.nlm.nih.gov/pubmed/23723238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1232044
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