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Peripheral Reduction of FGFR4 with Antisense Oligonucleotides Increases Metabolic Rate and Lowers Adiposity in Diet-Induced Obese Mice

Obesity is a primary risk factor for multiple metabolic disorders. Many drugs for the treatment of obesity, which mainly act through CNS as appetite suppressants, have failed during development or been removed from the market due to unacceptable adverse effects. Thus, there are very few efficacious...

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Bibliografiske detaljer
Main Authors: Yu, Xing Xian, Watts, Lynnetta M., Manchem, Vara Prasad, Chakravarty, Kaushik, Monia, Brett P., McCaleb, Michael L., Bhanot, Sanjay
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726752/
https://ncbi.nlm.nih.gov/pubmed/23922646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066923
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