Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice

Circulating transthyretin (TTR) is a critical determinant of plasma retinol-binding protein 4 (RBP4) levels. Elevated RBP4 levels cause insulin resistance, and the lowering of RBP4 levels improves glucose homeostasis. Since lowering TTR levels increases renal clearance of RBP4, we determined whether...

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Enregistré dans:
Détails bibliographiques
Publié dans:Diabetes
Auteurs principaux: Zemany, Laura, Bhanot, Sanjay, Peroni, Odile D., Murray, Susan F., Moraes-Vieira, Pedro M., Castoldi, Angela, Manchem, Prasad, Guo, Shuling, Monia, Brett P., Kahn, Barbara B.
Format: Artigo
Langue:Inglês
Publié: American Diabetes Association 2015
Sujets:
Metabolism
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4407860/
https://ncbi.nlm.nih.gov/pubmed/25524914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0970
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