Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching

The evolutionarily conserved kinase PIKfyve that synthesizes PtdIns5P and PtdIns(3,5)P(2) has been implicated in insulin-regulated GLUT4 translocation/glucose entry in 3T3-L1 adipocytes. To decipher PIKfyve's role in muscle and systemic glucose metabolism, here we have developed a novel mouse m...

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Detalhes bibliográficos
Main Authors: Ikonomov, Ognian C., Sbrissa, Diego, Delvecchio, Khortnal, Feng, Han-Zhong, Cartee, Gregory D., Jin, Jian-Ping, Shisheva, Assia
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725567/
https://ncbi.nlm.nih.gov/pubmed/23673157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00030.2013
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