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Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity, and hyperinsulinemia but not muscle fiber-type switching
The evolutionarily conserved kinase PIKfyve that synthesizes PtdIns5P and PtdIns(3,5)P(2) has been implicated in insulin-regulated GLUT4 translocation/glucose entry in 3T3-L1 adipocytes. To decipher PIKfyve's role in muscle and systemic glucose metabolism, here we have developed a novel mouse m...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Physiological Society
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3725567/ https://ncbi.nlm.nih.gov/pubmed/23673157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00030.2013 |
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