Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P(2) by means of the PIKfyve inhibitor YM201636

PIKfyve is an essential mammalian lipid kinase with pleiotropic cellular functions whose genetic knockout in mice leads to preimplantation lethality. Despite several reports for PIKfyve-catalyzed synthesis of phosphatidylinositol 5-phosphate (PtdIns5P) along with phosphatidylinositol-3,5-biphosphate...

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Detalhes bibliográficos
Main Authors: Sbrissa, Diego, Ikonomov, Ognian C., Filios, Catherine, Delvecchio, Khortnal, Shisheva, Assia
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422984/
https://ncbi.nlm.nih.gov/pubmed/22621786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00105.2012
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