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Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P(2) by means of the PIKfyve inhibitor YM201636

PIKfyve is an essential mammalian lipid kinase with pleiotropic cellular functions whose genetic knockout in mice leads to preimplantation lethality. Despite several reports for PIKfyve-catalyzed synthesis of phosphatidylinositol 5-phosphate (PtdIns5P) along with phosphatidylinositol-3,5-biphosphate...

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Detaylı Bibliyografya
Asıl Yazarlar: Sbrissa, Diego, Ikonomov, Ognian C., Filios, Catherine, Delvecchio, Khortnal, Shisheva, Assia
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422984/
https://ncbi.nlm.nih.gov/pubmed/22621786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00105.2012
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