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YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P(2) synthesis, halts glucose entry by insulin in adipocytes
Silencing of PIKfyve, the sole enzyme for PtdIns(3,5)P(2) biosynthesis that controls proper endosome dynamics, inhibits retroviral replication. A novel PIKfyve-specific inhibitor YM201636 disrupts retroviral budding at 800 nM, suggesting its potential use as an antiretroviral therapeutic. Because PI...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3910513/ https://ncbi.nlm.nih.gov/pubmed/19289105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.03.063 |
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