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Class III PI 3-Kinase is the Main Source of PtdIns3P Substrate and Membrane Recruitment Signal for PIKfyve Constitutive Function in Podocyte Endomembrane Homeostasis
The evolutionarily conserved PIKfyve, which synthesizes PtdIns5P from PtdIns, and PtdIns(3,5)P(2) from PtdIns3P, requires PtdIns3P as both an enzyme substrate and a membrane recruitment signal. Whereas the PtdIns3P source is undetermined, class III PI3K (Vps34), the only evolutionarily conserved of...
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| Pubblicato in: | Biochim Biophys Acta |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4431544/ https://ncbi.nlm.nih.gov/pubmed/25619930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2015.01.008 |
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