Class III PI 3-Kinase is the Main Source of PtdIns3P Substrate and Membrane Recruitment Signal for PIKfyve Constitutive Function in Podocyte Endomembrane Homeostasis

The evolutionarily conserved PIKfyve, which synthesizes PtdIns5P from PtdIns, and PtdIns(3,5)P(2) from PtdIns3P, requires PtdIns3P as both an enzyme substrate and a membrane recruitment signal. Whereas the PtdIns3P source is undetermined, class III PI3K (Vps34), the only evolutionarily conserved of...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Ikonomov, Ognian C., Sbrissa, Diego, Venkatareddy, Madhusudan, Tisdale, Ellen, Garg, Puneet, Shisheva, Assia
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4431544/
https://ncbi.nlm.nih.gov/pubmed/25619930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2015.01.008
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