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Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P(2) by means of the PIKfyve inhibitor YM201636
PIKfyve is an essential mammalian lipid kinase with pleiotropic cellular functions whose genetic knockout in mice leads to preimplantation lethality. Despite several reports for PIKfyve-catalyzed synthesis of phosphatidylinositol 5-phosphate (PtdIns5P) along with phosphatidylinositol-3,5-biphosphate...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Physiological Society
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3422984/ https://ncbi.nlm.nih.gov/pubmed/22621786 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00105.2012 |
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